ISSN: 0022-1198
CODEN: JFSCA
Published Online: 1 October 1981
Page Count: 41

Identification of Some Chemical Analogues and Positional Isomers of Methaqualone
Washington, O
Forensic chemists, Drug Enforcement Administration, North Central Regional Laboratory, Ill.

Angelos, SA
Forensic chemists, Drug Enforcement Administration, North Central Regional Laboratory, Ill.

Dal Cason, TA
Forensic chemists, Drug Enforcement Administration, North Central Regional Laboratory, Ill.

(Received 16 January 1981; accepted 27 March 1981)

Abstract

The drug 2-methyl-3-ortho-tolyl-4-quinazolinone (methaqualone) and 15 chemical analogues and positional isomers were synthesized and identified by spectroscopic techniques. The series of analogues studied includes the compounds formed through substitution of hydrogen or halogen atoms in place of the methyl group of the 3-tolyl substituent in methaqualone. Additionally, the substituent's positional orientation of ortho, meta, or para is considered. Infrared, nuclear magnetic resonance, and mass spectra of the compounds are distinctive, and reference spectra are provided. Gas-liquid and thin-layer chromatographic systems for analysis of the compounds as well as melting point and ultraviolet data are discussed.

Keywords:
toxicology, methaqualone, chemical analysis

Paper ID: JFS11434J
DOI: 10.1520/JFS11434J
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