Volume 26, Issue 4 (October 1981)

    Identification of Some Chemical Analogues and Positional Isomers of Methaqualone

    (Received 16 January 1981; accepted 27 March 1981)

    Published Online: October

    CODEN: JFSOAD

      Format Pages Price  
    PDF Version 41 $25   ADD TO CART


    Abstract

    The drug 2-methyl-3-ortho-tolyl-4-quinazolinone (methaqualone) and 15 chemical analogues and positional isomers were synthesized and identified by spectroscopic techniques. The series of analogues studied includes the compounds formed through substitution of hydrogen or halogen atoms in place of the methyl group of the 3-tolyl substituent in methaqualone. Additionally, the substituent's positional orientation of ortho, meta, or para is considered. Infrared, nuclear magnetic resonance, and mass spectra of the compounds are distinctive, and reference spectra are provided. Gas-liquid and thin-layer chromatographic systems for analysis of the compounds as well as melting point and ultraviolet data are discussed.


    Author Information:

    Washington, O
    Forensic chemists, Drug Enforcement Administration, North Central Regional Laboratory, Chicago, Ill.

    Angelos, SA
    Forensic chemists, Drug Enforcement Administration, North Central Regional Laboratory, Chicago, Ill.

    Dal Cason, TA
    Forensic chemists, Drug Enforcement Administration, North Central Regional Laboratory, Chicago, Ill.


    Stock #: JFS11434J

    ISSN: 0022-1198

    DOI: 10.1520/JFS11434J

    ASTM International
    is a member of CrossRef.

    Author
    Title Identification of Some Chemical Analogues and Positional Isomers of Methaqualone
    Symposium , 0000-00-00
    Committee E30