Volume 26, Issue 4 (October 1981)

    Approaches to Drug Sample Differentiation. II: Nuclear Magnetic Resonance Spectrometric Determination of Methamphetamine Enantiomers

    (Received 26 January 1981; accepted 14 April 1981)

    Published Online: October

    CODEN: JFSOAD

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    Abstract

    Synthesized tris[d,d-dicampholylmethanato]europium(III), Eu(dcm)3, and three other commercially available chiral lanthanide shift reagents are used to resolve the nuclear magnetic resonance (NMR) spectra of the enantiomeric N-CH3 and C-CH3 protons in d- and l-methamphetamine. The chemical shift difference between the corresponding enantiomeric protons induced by these four shift reagents are compared and evaluated in their prospective use for enantiomeric identification and determination. It is concluded that while the chemical shift difference between the two enantiomerie C-CH3 protons induced by Eu(dcm)3 is most suitable for qualitative identification of these enantiomers, the NMR spectra of the N-CH3 protons are best resolved by Eu(dcm)3 and most suitable for quantitative determinations.


    Author Information:

    Lins, CLK
    Research associate, University of Illinois at the Medical Center, Chicago, Ill.

    Liu, JH
    Assistant professor, graduate student, graduate student, and graduate student, University of Illinois at Chicago Circle, Chicago, Ill.

    Tsay, JT
    Assistant professor, graduate student, graduate student, and graduate student, University of Illinois at Chicago Circle, Chicago, Ill.

    Fitzgerald, MP
    Assistant professor, graduate student, graduate student, and graduate student, University of Illinois at Chicago Circle, Chicago, Ill.

    Angelos, SA
    Forensic chemist, North Central Regional Laboratory, Drug Enforcement Administration, Chicago, Ill.

    Ramesh, S
    Research associate, University of Illinois at Chicago Circle, Chicago, Ill.

    Ku, WW
    Assistant professor, graduate student, graduate student, and graduate student, University of Illinois at Chicago Circle, Chicago, Ill.


    Stock #: JFS11419J

    ISSN: 0022-1198

    DOI: 10.1520/JFS11419J

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    Title Approaches to Drug Sample Differentiation. II: Nuclear Magnetic Resonance Spectrometric Determination of Methamphetamine Enantiomers
    Symposium , 0000-00-00
    Committee E30