ISSN: 0022-1198
CODEN: JFSCA
Published Online: 1 October 1981
Page Count: 8

Approaches to Drug Sample Differentiation. II: Nuclear Magnetic Resonance Spectrometric Determination of Methamphetamine Enantiomers
Lins, CLK
Research associate, University of Illinois at the Medical Center, Ill.

Liu, JH
Assistant professor, graduate student, graduate student, and graduate student, University of Illinois at Chicago Circle, Ill.

Tsay, JT
Assistant professor, graduate student, graduate student, and graduate student, University of Illinois at Chicago Circle, Ill.

Fitzgerald, MP
Assistant professor, graduate student, graduate student, and graduate student, University of Illinois at Chicago Circle, Ill.

Angelos, SA
Forensic chemist, North Central Regional Laboratory, Drug Enforcement Administration, Ill.

Ramesh, S
Research associate, University of Illinois at Chicago Circle, Ill.

Ku, WW
Assistant professor, graduate student, graduate student, and graduate student, University of Illinois at Chicago Circle, Ill.

(Received 26 January 1981; accepted 14 April 1981)

Abstract

Synthesized tris[d,d-dicampholylmethanato]europium(III), Eu(dcm)³, and three other commercially available chiral lanthanide shift reagents are used to resolve the nuclear magnetic resonance (NMR) spectra of the enantiomeric N-CH³ and C-CH³ protons in d- and l-methamphetamine. The chemical shift difference between the corresponding enantiomeric protons induced by these four shift reagents are compared and evaluated in their prospective use for enantiomeric identification and determination. It is concluded that while the chemical shift difference between the two enantiomerie C-CH³ protons induced by Eu(dcm)³ is most suitable for qualitative identification of these enantiomers, the NMR spectra of the N-CH³ protons are best resolved by Eu(dcm)³ and most suitable for quantitative determinations.

Keywords:
toxicology, drug identification, chemical analysis, enantiomer, chiral shift reagent, amphetamine, methamphetamine

Paper ID: JFS11419J
DOI: 10.1520/JFS11419J
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