ISSN: 0022-1198
CODEN: JFSCA
Published Online: 1 October 1981
Page Count: 5

Approaches to Drug Sample Differentiation. I: A Conceptual Review
Liu, JH
Assistant professor, University of Illinois at Chicago Circle, Ill.

(Received 26 January 1981; accepted 14 April 1981)

Abstract

Differentiation of drug samples can be based on at least three different approaches. Conventional methods use qualitative and quantitative determinations of impurities or minor components. Samples may also be differentiated by variations in a naturally occurring isotope such as carbon-13, whose content varies because of differences of carbon fixation conditions for cultivated plant drugs or from differences in reaction conditions for synthesized drugs. A third approach involves the determination of various diastereoisomeric or enantiomeric compositions or both. This last approach also serves an essential purpose in cases where one isomer is under regulation while other(s) may not be. Representative works are reviewed.

Keywords:
toxicology, drug identification, chemical analysis, sample differentiation, isotope ratio, diastereoisomer, enantiomer, chiral lanthanide shift reagent, chiral stationary phase

Paper ID: JFS11418J
DOI: 10.1520/JFS11418J
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