Approaches to Drug Sample Differentiation. I: A Conceptual Review

    Volume 26, Issue 4 (October 1981)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 October 1981

    Page Count: 5


    Liu, JH
    Assistant professor, University of Illinois at Chicago Circle, Chicago, Ill.

    (Received 26 January 1981; accepted 14 April 1981)

    Abstract

    Differentiation of drug samples can be based on at least three different approaches. Conventional methods use qualitative and quantitative determinations of impurities or minor components. Samples may also be differentiated by variations in a naturally occurring isotope such as carbon-13, whose content varies because of differences of carbon fixation conditions for cultivated plant drugs or from differences in reaction conditions for synthesized drugs. A third approach involves the determination of various diastereoisomeric or enantiomeric compositions or both. This last approach also serves an essential purpose in cases where one isomer is under regulation while other(s) may not be. Representative works are reviewed.


    Paper ID: JFS11418J

    DOI: 10.1520/JFS11418J

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    Author
    Title Approaches to Drug Sample Differentiation. I: A Conceptual Review
    Symposium , 0000-00-00
    Committee E30