The Use of Carbon-13 Nuclear Magnetic Resonance Spectra in the Identification and Authentication of Monomethoxyamphetamines and Dimethoxyamphetamines

    Volume 26, Issue 1 (January 1981)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 January 1981

    Page Count: 8


    Legault, D
    Chief, Drug Research Laboratories, Health Protection Branch, Tunney's Pasture, Ottawa,

    Bailey, K
    Chief, Drug Research Laboratories, Health Protection Branch, Tunney's Pasture, Ottawa,

    (Received 29 December 1979; accepted 22 May 1980)

    Abstract

    The 13C nuclear magnetic resonance (NMR) spectra of amphetamine, the three monomethoxyamphetamines, and the six dimethoxyamphetamines and their hyrochlorides were determined. The spectra are distinctive and suitable for identification and authentication purposes. The signals may be assigned by comparisons of chemical shifts with those of model compounds and by an internally consistent analysis of chemical shift differences, supported by the results of appropriate proton-decoupling techniques. Data from the spectra and details of their interpretation are presented. Ortho methoxyl groups relatively shield the α andβ side-chain carbon signals. The ring substituents affect the resonances of the ring carbons in a consistent manner. The data should be valuable in the forensic science identification and structural authentication of these and related substances and further confirm the power of 13C NMR spectroscopy in distinguishing between isomeric structures.


    Paper ID: JFS11326J

    DOI: 10.1520/JFS11326J

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    Title The Use of Carbon-13 Nuclear Magnetic Resonance Spectra in the Identification and Authentication of Monomethoxyamphetamines and Dimethoxyamphetamines
    Symposium , 0000-00-00
    Committee E30