ISSN: 0022-1198
CODEN: JFSCA
Published Online: 1 January 1981
Page Count: 8

The Use of Carbon-13 Nuclear Magnetic Resonance Spectra in the Identification and Authentication of Monomethoxyamphetamines and Dimethoxyamphetamines
Legault, D
Chief, Drug Research Laboratories, Health Protection Branch, Tunney's Pasture,

Bailey, K
Chief, Drug Research Laboratories, Health Protection Branch, Tunney's Pasture,

(Received 29 December 1979; accepted 22 May 1980)

Abstract

The ¹³C nuclear magnetic resonance (NMR) spectra of amphetamine, the three monomethoxyamphetamines, and the six dimethoxyamphetamines and their hyrochlorides were determined. The spectra are distinctive and suitable for identification and authentication purposes. The signals may be assigned by comparisons of chemical shifts with those of model compounds and by an internally consistent analysis of chemical shift differences, supported by the results of appropriate proton-decoupling techniques. Data from the spectra and details of their interpretation are presented. Ortho methoxyl groups relatively shield the α andβ side-chain carbon signals. The ring substituents affect the resonances of the ring carbons in a consistent manner. The data should be valuable in the forensic science identification and structural authentication of these and related substances and further confirm the power of ¹³C NMR spectroscopy in distinguishing between isomeric structures.

Keywords:
toxicology, chemical analysis, amphetamine

Paper ID: JFS11326J
DOI: 10.1520/JFS11326J
ASTM International is a member of CrossRef.