Volume 26, Issue 1 (January 1981)
The Use of Carbon-13 Nuclear Magnetic Resonance Spectra in the Identification and Authentication of Monomethoxyamphetamines and Dimethoxyamphetamines
The 13C nuclear magnetic resonance (NMR) spectra of amphetamine, the three monomethoxyamphetamines, and the six dimethoxyamphetamines and their hyrochlorides were determined. The spectra are distinctive and suitable for identification and authentication purposes. The signals may be assigned by comparisons of chemical shifts with those of model compounds and by an internally consistent analysis of chemical shift differences, supported by the results of appropriate proton-decoupling techniques. Data from the spectra and details of their interpretation are presented. Ortho methoxyl groups relatively shield the α andβ side-chain carbon signals. The ring substituents affect the resonances of the ring carbons in a consistent manner. The data should be valuable in the forensic science identification and structural authentication of these and related substances and further confirm the power of 13C NMR spectroscopy in distinguishing between isomeric structures.