Low Resolution Electron Impact Mass Spectra of Some Quinuclidine and N-Methylpiperidine Glycolates

    Volume 25, Issue 3 (July 1980)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 July 1980

    Page Count: 11


    Fisher, A
    Head, Analytical Chemistry; chemical technician; biomedical research chemist; and mass spectrometrist, Israel Institute for Biological Research, Ness-Ziona,

    Vincze, A
    Head, Analytical Chemistry; chemical technician; biomedical research chemist; and mass spectrometrist, Israel Institute for Biological Research, Ness-Ziona,

    Gefen, L
    Head, Analytical Chemistry; chemical technician; biomedical research chemist; and mass spectrometrist, Israel Institute for Biological Research, Ness-Ziona,

    Bel, P
    Head, Analytical Chemistry; chemical technician; biomedical research chemist; and mass spectrometrist, Israel Institute for Biological Research, Ness-Ziona,

    (Received 15 November 1979; accepted 3 January 1980)

    Abstract

    Quinuclidine and N-methylpiperidine glycolates of the general formula PhC(OH)(R)COOR', where Ph is phenyl, R is phenyl or alkyl, and R' the cyclic amine moiety, are known antidepressant and hallucinogenic compounds. Mass spectra of these are scarcely described in the literature and are the subject of this communication. Low resolution electron impact spectra were studied at 70 and low electron volts. The main fragmentation patterns and rearrangements, supported by study of deuterated analogs, are described. Determination of M+ and two other characteristic ions gives a good knowledge of the compound at hand while recognition of a few more fragments is necessary for an exact knowledge of the specific structure. The spectra and availability of deuterated analogs may lead to development of specific, sensitive methods of analysis for these biologically active compounds.


    Paper ID: JFS11270J

    DOI: 10.1520/JFS11270J

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    Title Low Resolution Electron Impact Mass Spectra of Some Quinuclidine and N-Methylpiperidine Glycolates
    Symposium , 0000-00-00
    Committee E30