A Study of the Myocardial Depressant Factor and Its Relative Influence in Drug/Alcohol Mortality

    Volume 25, Issue 3 (July 1980)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 July 1980

    Page Count: 14


    Bidanset, JH
    Professor and chairman, St. John's University, Jamaica, N.Y.

    Williams, LE
    Director of cardiac and cardiovascular surgery, Nassau County Medical Center, East Meadow, N.Y.

    Lukash, L
    Chief toxicologist, forensic medical investigator, and chief medical examiner, Nassau County Medical Examiner's Office, East Meadow, N.Y.

    Manning, TJ
    Chief toxicologist, forensic medical investigator, and chief medical examiner, Nassau County Medical Examiner's Office, East Meadow, N.Y.

    Lynch, VD
    Professor and chairman, St. John's University, Jamaica, N.Y.

    Drake, W
    Chief toxicologist, forensic medical investigator, and chief medical examiner, Nassau County Medical Examiner's Office, East Meadow, N.Y.

    (Received 19 July 1979; accepted 13 November 1979)

    Abstract

    A shock factor, a low molecular weight peptide, has been isolated from postmortem blood. High levels of this peptide, which depresses the myocardium, were seen in cases where drug overdose or alcoholism, or both, were the cause of death. An elevated myocardial depressant factor (MDF) level was also demonstrated in a fire victim and a patient in cardiogenic shock. The peptide analysis was accomplished by using an isolated cat papillary muscle followed by paper chromatographic confirmation. Postmortem electrolytes, alcohol, and various toxic agents were eliminated as causes of myocardial depression in the isolated cat papillary muscle assay. The presence of elevated MDF levels may be significant in the overall death process.


    Paper ID: JFS11257J

    DOI: 10.1520/JFS11257J

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    Title A Study of the Myocardial Depressant Factor and Its Relative Influence in Drug/Alcohol Mortality
    Symposium , 0000-00-00
    Committee E30