ISSN: 0022-1198
CODEN: JFSCA
Published Online: 1 November 1987
Page Count: 13

Comparison of Drug Retention Indices Determined on Packed, Wide Bore Capillary and Narrow Bore Capillary Columns
David Osselton, M
Higher scientific officer, senior scientific officer, and principal scientific officer, Central Research Establishment, Home Office Forensic Science Service,

Japp, M
Higher scientific officer, senior scientific officer, and principal scientific officer, Central Research Establishment, Home Office Forensic Science Service,

Gill, R
Higher scientific officer, senior scientific officer, and principal scientific officer, Central Research Establishment, Home Office Forensic Science Service,

(Received 16 January 1987; accepted 6 April 1987)

Abstract

The retention indices of 75 drugs and other compounds of toxicological significance have been measured on SE-30 equivalent, chemically bonded, fused silica capillary columns under isothermal conditions. The data have been assessed to determine the validity of using retention indices measured on packed columns for the identification of compounds eluting from narrow bore thin film or wide bore thick film capillary columns. The results indicate that the extensive retention index data bases published for SE-30 packed columns may be used for the preliminary identification of peaks eluting from capillary columns in toxicological screening. The study also indicates that retention index data bases generated on narrow bore capillary columns are applicable to wide bore thick film capillary columns.

Keywords:
toxicology, drug retention indices, chromatographic analysis

Paper ID: JFS11217J
DOI: 10.1520/JFS11217J
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