ISSN: 0022-1198
CODEN: JFSCA
Published Online: 1 September 1987
Page Count: 10

Abuse of Smoking Methamphetamine Mixed with Tobacco: I. Inhalation Efficiency and Pyrolysis Products of Methamphetamine
Sekine, H
Criminal Investigation Laboratory, Saitama Prefecture Police Headquarters,

Nakahara, Y
Chief, Narcotic Section, National Institute of Hygienic Science,

(Received 29 December 1986; accepted 16 January 1987)

Abstract

Experiments of smoking methamphetamine in tobacco have been investigated. Inhalation efficiencies of methamphetamine into tar were 6 to 17% according to the additive amounts, suction volume, and intervals of smoking. Major pyrolysis products of methamphetamine in tar were identified as methamphetamine, amphetamine, phenylacetone, dimethylamphetamine, N-formyl-, N-acetyl-, N-propionyl-, and N-cyanomethyl-methamphetamine by the spectral analysis of infrared spectra (IR), mass spectra (MS), and proton magnetic resonance spectra (PMR), and comparison with the samples synthesized from authentic samples by one step. The largest pyrolysis product was N-cyanomethylmethamphetamine which is a new compound and easily metabolized to methamphetamine in the body. Methamphetamine itself transferred into tar was not so large, but the total active compounds in tar which would be metabolized to methamphetamine in the body were considerably larger.

Keywords:
toxicology, methamphetamine, tobacco, pyrolysis, drug abuse, smoking experiment, pyrolysis products

Paper ID: JFS11178J
DOI: 10.1520/JFS11178J
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