Volume 32, Issue 2 (March 1987)

    Analysis of 2-Hydroxyimipramine in an Imipramine-Related Fatality

    (Received 29 January 1986; accepted 14 April 1986)

    Published Online: March

    CODEN: JFSOAD

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    Abstract

    A fatality following ingestion of the tricyclic antidepressant imipramine (Novopramine®), acetaminophen, and ethyl alcohol is described. Imipramine, desipramine, acetaminophen, and 2-hydroxyimipramine were quantitated by high performance liquid chromatography, and ethyl alcohol by gas liquid chromatography. Concentrations of imipramine, desipramine, 2-hydroxyimipramine, and acetaminophen were: in blood—9.0, 1.1, 3.9, and 11 mg/L; in urine—92, 14, and 42 mg/L (acetaminophen not quantitated in urine). Ethyl alcohol concentration in blood was <10 mg/dL and 105 mg/dL in the urine by headspace gas chromatography. These findings are compared to previous reports of imipramine-related fatalities. To our knowledge, this is the first fatality reported involving imipramine where analysis included quantitation of 2-hydroxyimipramine in blood and urine.


    Author Information:

    Fraser, AD
    Head, Toxicology Laboratory, Victoria General Hospital, Halifax, Nova Scotia

    Isner, AF
    Technologist, Toxicology Laboratory, Victoria General Hospital, Halifax, Nova Scotia

    Susnik, E
    Technologist, Toxicology Laboratory, Victoria General Hospital, Halifax, Nova Scotia


    Stock #: JFS11159J

    ISSN: 0022-1198

    DOI: 10.1520/JFS11159J

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    Author
    Title Analysis of 2-Hydroxyimipramine in an Imipramine-Related Fatality
    Symposium , 0000-00-00
    Committee E30