Central Pontine Myelinolysis: A Complication of Hyponatremia or of Therapeutic Intervention?

    Volume 32, Issue 2 (March 1987)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 March 1987

    Page Count: 8


    Haibach, H
    Associate professor of pathology and medicine and assistant professor of pathology, University of Missouri-Columbia, School of Medicine, Columbia, MO

    Dix, JD
    Assistant professor of pathology, University of Missouri-Columbia, School of Medicine, Columbia, Columbia

    Ansbacher, LE
    Associate professor of pathology and medicine and assistant professor of pathology, University of Missouri-Columbia, School of Medicine, Columbia, MO

    (Received 7 April 1986; accepted 19 May 1986)

    Abstract

    We report four cases of central pontine myelinolysis (CPM) that illustrate important features of the disorder. The condition is described mainly in the neurological literature and, to our knowledge, is not discussed in the forensic science journals. This disorder must be recognized and understood by the forensic science expert who addresses issues of liability. In cases of multiple motor deficits and death with a history of hyponatremia, CPM must be included in the differential diagnosis. Careful examination of the pons and adjoining structures must be performed. Myelin stains are advisable. The association of CPM with major illnesses, hyponatremia and the correction of hyponatremia by intravenous saline infusions is discussed.


    Paper ID: JFS11146J

    DOI: 10.1520/JFS11146J

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    Title Central Pontine Myelinolysis: A Complication of Hyponatremia or of Therapeutic Intervention?
    Symposium , 0000-00-00
    Committee E30