ISSN: 0022-1198
CODEN: JFSCA
Published Online: 1 July 1985
Page Count: 7

¹H Nuclear Magnetic Resonance of Heroin's D Ring
Allen, AC
Forensic chemists, Drug Enforcement Administration, Special Testing and Research Laboratory, VA

Cooper, DA
Forensic chemists, Drug Enforcement Administration, Special Testing and Research Laboratory, VA

Moore, JM
Forensic chemists, Drug Enforcement Administration, Special Testing and Research Laboratory, VA

(Received 11 August 1984; accepted 12 October 1984)

Abstract

The ¹H nuclear magnetic resonance (NMR) chemical shifts and coupling constants of heroin's (1) D ring H-15^α, H-15^β, and H-16^α, and H-16^β are presented. These assignments were accessible through the introduction of a double bond (Δ^15,16) in heroin. The resulting compound, Δ^15,16 didehydroheroin (2), was subjected to deuterium exchange or stereoselective reduction or both. Reduced products d¹-16^αheroin (3), d²-15^α, 15^β-heroin (4), and d³-15^α, 15^β, 16^α-heroin (5) are presented. Heroin with deuterated acetyls is also presented for ¹H NMR spectral clarity in the D ring area.

Keywords:
toxicology, heroin, chemical analysis

Paper ID: JFS11025J
DOI: 10.1520/JFS11025J
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