Volume 24, Issue 4 (October 1979)

    Detection of Drugs Using XAD-2 Resin. III: A Routine Screening Procedure for Bile

    (Received 6 February 1979; accepted 27 April 1979)

    Published Online: October

    CODEN: JFSOAD

      Format Pages Price  
    PDF 7 $25   ADD TO CART


    Abstract

    A number of biological specimens may be routinely examined in medical examiner's cases. A useful specimen for toxicologic analysis is one that by its physiological nature concentrates drugs in easily detectable amounts, is readily available in sufficient quantity, does not require extensive preparation, and is applicable to simple screening techniques. Urine has been particularly amenable to XAD-2 resin screening [1–11]. However, in postmortem cases urine is often unavailable and bile becomes the sample of choice. Simple hydrolysis alters the consistency of bile so that it can be readily extracted by the XAD-2 resin methods [12,13]. In addition, the disposition and biotransformation of many drugs causes significant quantities of parent drugs and metabolites to be found in bile, often in concentrations higher than those in other biological specimens.


    Author Information:

    Thompson, BC
    Chief toxicologist and assistant toxicologist, Office of the Chief Medical Examiner, Baltimore, State of Maryland

    Stajić, M
    Toxicologist, Commonwealth of Virginia, Department of General Services, Division of Consolidated Laboratory Services, Bureau of Forensic Science, Merrifield, Va

    Backer, RC
    Chief toxicologist, Office of the Chief Medical Examiner, South Charleston, State of West Virginia

    Caplan, YH
    Chief toxicologist and assistant toxicologist, Office of the Chief Medical Examiner, Baltimore, State of Maryland


    Stock #: JFS10901J

    ISSN: 0022-1198

    DOI: 10.1520/JFS10901J

    ASTM International
    is a member of CrossRef.

    Author
    Title Detection of Drugs Using XAD-2 Resin. III: A Routine Screening Procedure for Bile
    Symposium , 0000-00-00
    Committee E30