Detection of Drugs Using XAD-2 Resin. III: A Routine Screening Procedure for Bile

    Volume 24, Issue 4 (October 1979)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 October 1979

    Page Count: 7


    Thompson, BC
    Chief toxicologist and assistant toxicologist, Office of the Chief Medical Examiner, Baltimore, State of Maryland

    Stajić, M
    Toxicologist, Commonwealth of Virginia, Department of General Services, Division of Consolidated Laboratory Services, Bureau of Forensic Science, Merrifield, Va

    Backer, RC
    Chief toxicologist, Office of the Chief Medical Examiner, South Charleston, State of West Virginia

    Caplan, YH
    Chief toxicologist and assistant toxicologist, Office of the Chief Medical Examiner, Baltimore, State of Maryland

    (Received 6 February 1979; accepted 27 April 1979)

    Abstract

    A number of biological specimens may be routinely examined in medical examiner's cases. A useful specimen for toxicologic analysis is one that by its physiological nature concentrates drugs in easily detectable amounts, is readily available in sufficient quantity, does not require extensive preparation, and is applicable to simple screening techniques. Urine has been particularly amenable to XAD-2 resin screening [1–11]. However, in postmortem cases urine is often unavailable and bile becomes the sample of choice. Simple hydrolysis alters the consistency of bile so that it can be readily extracted by the XAD-2 resin methods [12,13]. In addition, the disposition and biotransformation of many drugs causes significant quantities of parent drugs and metabolites to be found in bile, often in concentrations higher than those in other biological specimens.


    Paper ID: JFS10901J

    DOI: 10.1520/JFS10901J

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    Title Detection of Drugs Using XAD-2 Resin. III: A Routine Screening Procedure for Bile
    Symposium , 0000-00-00
    Committee E30