Journal Published Online: 01 October 1979
Volume 24, Issue 4

Detection of Drugs Using XAD-2 Resin. I: Choice of Resin, Chromatographic Conditions, and Recovery Studies

CODEN: JFSCAS

Abstract

In 1969 Fujimoto and Wang [1] introduced a new drug extraction technique when they applied Amberlite®XAD-2 a nonionic polystyrene divinylbenzene resin, to the analysis of narcotic analgesics in urine. The resin was prepared by washing it with water and methanol, and after the urine sample was poured through a column containing the resin the adsorbed drugs were eluted with methanol and subsequently analyzed by thin-layer chromatography (TLC). Morphine, meperidine, codeine, methadone, levorphanol, pentazocine, and dihydromorphinone were detected in therapeutic concentrations. Many modifications of the original procedure successfully applied XAD-2 and other similar resins to the extraction of drugs from urine and, more recently, other biological fluids and tissues.

Author Information

Stajić, M
Commonwealth of Virginia, Department of General Services, Division of Consolidated Laboratory Services, Bureau of Forensic Science, Merrifield, Va
Caplan, YH
Office of the Chief Medical Examiner, Baltimore, Md
Backer, RC
Office of the Chief Medical Examiner, South Charleston, W. Va
Pages: 10
Price: $25.00
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Stock #: JFS10899J
ISSN: 0022-1198
DOI: 10.1520/JFS10899J