Volume 24, Issue 4 (October 1979)

    Detection of Drugs Using XAD-2 Resin. I: Choice of Resin, Chromatographic Conditions, and Recovery Studies

    (Received 6 February 1979; accepted 27 April 1979)

    Published Online: October

    CODEN: JFSOAD

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    Abstract

    In 1969 Fujimoto and Wang [1] introduced a new drug extraction technique when they applied Amberlite®XAD-2 a nonionic polystyrene divinylbenzene resin, to the analysis of narcotic analgesics in urine. The resin was prepared by washing it with water and methanol, and after the urine sample was poured through a column containing the resin the adsorbed drugs were eluted with methanol and subsequently analyzed by thin-layer chromatography (TLC). Morphine, meperidine, codeine, methadone, levorphanol, pentazocine, and dihydromorphinone were detected in therapeutic concentrations. Many modifications of the original procedure successfully applied XAD-2 and other similar resins to the extraction of drugs from urine and, more recently, other biological fluids and tissues.


    Author Information:

    Stajić, M
    Toxicologist, Commonwealth of Virginia, Department of General Services, Division of Consolidated Laboratory Services, Bureau of Forensic Science, Merrifield, Va

    Backer, RC
    Chief toxicologist, Office of the Chief Medical Examiner, South Charleston, State of West Virginia

    Caplan, YH
    Chief toxicologist, Office of the Chief Medical Examiner, Baltimore, State of Maryland


    Stock #: JFS10899J

    ISSN: 0022-1198

    DOI: 10.1520/JFS10899J

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    Author
    Title Detection of Drugs Using XAD-2 Resin. I: Choice of Resin, Chromatographic Conditions, and Recovery Studies
    Symposium , 0000-00-00
    Committee E30