Detection of Drugs Using XAD-2 Resin. I: Choice of Resin, Chromatographic Conditions, and Recovery Studies

    Volume 24, Issue 4 (October 1979)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 October 1979

    Page Count: 10


    Stajić, M
    Toxicologist, Commonwealth of Virginia, Department of General Services, Division of Consolidated Laboratory Services, Bureau of Forensic Science, Merrifield, Va

    Backer, RC
    Chief toxicologist, Office of the Chief Medical Examiner, South Charleston, State of West Virginia

    Caplan, YH
    Chief toxicologist, Office of the Chief Medical Examiner, Baltimore, State of Maryland

    (Received 6 February 1979; accepted 27 April 1979)

    Abstract

    In 1969 Fujimoto and Wang [1] introduced a new drug extraction technique when they applied Amberlite®XAD-2 a nonionic polystyrene divinylbenzene resin, to the analysis of narcotic analgesics in urine. The resin was prepared by washing it with water and methanol, and after the urine sample was poured through a column containing the resin the adsorbed drugs were eluted with methanol and subsequently analyzed by thin-layer chromatography (TLC). Morphine, meperidine, codeine, methadone, levorphanol, pentazocine, and dihydromorphinone were detected in therapeutic concentrations. Many modifications of the original procedure successfully applied XAD-2 and other similar resins to the extraction of drugs from urine and, more recently, other biological fluids and tissues.


    Paper ID: JFS10899J

    DOI: 10.1520/JFS10899J

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    Title Detection of Drugs Using XAD-2 Resin. I: Choice of Resin, Chromatographic Conditions, and Recovery Studies
    Symposium , 0000-00-00
    Committee E30