Published Online: 1 October 1979
Page Count: 10
Toxicologist, Commonwealth of Virginia, Department of General Services, Division of Consolidated Laboratory Services, Bureau of Forensic Science, Merrifield, Va
Chief toxicologist, Office of the Chief Medical Examiner, South Charleston, State of West Virginia
Chief toxicologist, Office of the Chief Medical Examiner, Baltimore, State of Maryland
(Received 6 February 1979; accepted 27 April 1979)
In 1969 Fujimoto and Wang  introduced a new drug extraction technique when they applied Amberlite®XAD-2 a nonionic polystyrene divinylbenzene resin, to the analysis of narcotic analgesics in urine. The resin was prepared by washing it with water and methanol, and after the urine sample was poured through a column containing the resin the adsorbed drugs were eluted with methanol and subsequently analyzed by thin-layer chromatography (TLC). Morphine, meperidine, codeine, methadone, levorphanol, pentazocine, and dihydromorphinone were detected in therapeutic concentrations. Many modifications of the original procedure successfully applied XAD-2 and other similar resins to the extraction of drugs from urine and, more recently, other biological fluids and tissues.
Paper ID: JFS10899J