The Effect of Time of Death on Extravascular Tissue/Blood Secobarbital Concentration Ratios in the Rat

    Volume 24, Issue 3 (July 1979)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 July 1979

    Page Count: 7


    Forney, RB
    Graduate student and professor, Indiana University School of Medicine, Indianapolis,

    Wolen, RL
    Research advisor, Lilly Laboratory for Clinical Research, Wishard Memorial Hospital, Indianapolis

    Orzelek, RM
    Graduate student and professor, Indiana University School of Medicine, Indianapolis,

    (Received 5 August 1978; accepted 29 December 1978)

    Abstract

    The concentration of a drug in the liver is often significantly higher than its concentration in the blood [1]. Curry and Sunshine [2] obtained data from 52 cases of barbiturate poisoning involving quick- or intermediate-acting barbiturates in which some information was available on the time between drug ingestion and death. It was observed that when the liver/blood ratio was greater than 4, death had usually occurred within 5 h of ingestion, and when the liver/blood ratio was less than 4, no relationship between time of drug ingestion and death was indicated.


    Paper ID: JFS10868J

    DOI: 10.1520/JFS10868J

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    Title The Effect of Time of Death on Extravascular Tissue/Blood Secobarbital Concentration Ratios in the Rat
    Symposium , 0000-00-00
    Committee E30