Journal Published Online: 01 July 1979
Volume 24, Issue 3

The Effect of Time of Death on Extravascular Tissue/Blood Secobarbital Concentration Ratios in the Rat

CODEN: JFSCAS

Abstract

The concentration of a drug in the liver is often significantly higher than its concentration in the blood [1]. Curry and Sunshine [2] obtained data from 52 cases of barbiturate poisoning involving quick- or intermediate-acting barbiturates in which some information was available on the time between drug ingestion and death. It was observed that when the liver/blood ratio was greater than 4, death had usually occurred within 5 h of ingestion, and when the liver/blood ratio was less than 4, no relationship between time of drug ingestion and death was indicated.

Author Information

Orzelek, RM
Indiana University School of Medicine, Indianapolis
Wolen, RL
Lilly Laboratory for Clinical Research, Wishard Memorial Hospital, Indianapolis, Ind.
Forney, RB
Indiana University School of Medicine, Indianapolis
Pages: 7
Price: $25.00
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Stock #: JFS10868J
ISSN: 0022-1198
DOI: 10.1520/JFS10868J