Volume 24, Issue 3 (July 1979)
The Effect of Time of Death on Extravascular Tissue/Blood Secobarbital Concentration Ratios in the Rat
The concentration of a drug in the liver is often significantly higher than its concentration in the blood . Curry and Sunshine  obtained data from 52 cases of barbiturate poisoning involving quick- or intermediate-acting barbiturates in which some information was available on the time between drug ingestion and death. It was observed that when the liver/blood ratio was greater than 4, death had usually occurred within 5 h of ingestion, and when the liver/blood ratio was less than 4, no relationship between time of drug ingestion and death was indicated.