Volume 24, Issue 2 (April 1979)
Hereditary Angioneurotic Edema: An Unusual Case of Maternal Mortality
Hereditary angioneurotic edema is an autosomal dominant, nonallergic disorder characterized by recurrent attacks of brawny edema of the extremities, face, larynx, and genitalia  and biochemically by a reduction in the serum protein C1 esterase inhibitor, a factor which prevents the activation of the first component of the complement system . Although most attacks are precipitated by trauma , there have been no previously reported cases in pregnancy during delivery or in the immediate postpartum period, despite obvious traumatic injury during the birth process. This report describes a patient who, following delivery, developed localized perineal swelling, which over 72 h progressed to generalized edema, terminating in irreversible shock.