Volume 24, Issue 1 (January 1979)

    Concentrations of Phenobarbital, Flurazepam, and Flurazepam Metabolites in Autopsy Cases

    (Received 21 March 1978; accepted 29 June 1978)

    Published Online: January

    CODEN: JFSOAD

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    Abstract

    Flurazepam hydrochloride (7-chloro-1-(diethylaminoethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride) was synthesized in 1965 by Sternbach et al [1]. It is used clinically as a hypnotic in the treatment of anxiety and depression syndromes as well as an anticonvulsant in association with other drugs. Its pharmacology and metabolism have been extensively studied by various workers [2–4]. The toxicological features of phenobarbital (ethylphenylbarbituric acid) are also almost completely known, and this compound has been used for years as the basic drug in the treatment of various clinical forms of epilepsy.


    Author Information:

    Castagna, F
    Director, Toxicology Section; laurea in chemistry, forensic toxicologist, assistant of the Toxicology Section; professor of legal medicine; and laurea in biology, forensic toxicologist, assistant of the Toxicology Section, Istituto Medicina Legale, Padua,

    Tedeschi, L
    Director, Toxicology Section; laurea in chemistry, forensic toxicologist, assistant of the Toxicology Section; professor of legal medicine; and laurea in biology, forensic toxicologist, assistant of the Toxicology Section, Istituto Medicina Legale, Padua,

    Marigo, M
    Director, Toxicology Section; laurea in chemistry, forensic toxicologist, assistant of the Toxicology Section; professor of legal medicine; and laurea in biology, forensic toxicologist, assistant of the Toxicology Section, Istituto Medicina Legale, Padua,

    Ferrara, SD
    Director, Toxicology Section; laurea in chemistry, forensic toxicologist, assistant of the Toxicology Section; professor of legal medicine; and laurea in biology, forensic toxicologist, assistant of the Toxicology Section, Istituto Medicina Legale, Padua,


    Stock #: JFS10790J

    ISSN: 0022-1198

    DOI: 10.1520/JFS10790J

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    Author
    Title Concentrations of Phenobarbital, Flurazepam, and Flurazepam Metabolites in Autopsy Cases
    Symposium , 0000-00-00
    Committee E30