Journal Published Online: 01 January 1979
Volume 24, Issue 1

Concentrations of Phenobarbital, Flurazepam, and Flurazepam Metabolites in Autopsy Cases

CODEN: JFSCAS

Abstract

Flurazepam hydrochloride (7-chloro-1-(diethylaminoethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride) was synthesized in 1965 by Sternbach et al [1]. It is used clinically as a hypnotic in the treatment of anxiety and depression syndromes as well as an anticonvulsant in association with other drugs. Its pharmacology and metabolism have been extensively studied by various workers [2–4]. The toxicological features of phenobarbital (ethylphenylbarbituric acid) are also almost completely known, and this compound has been used for years as the basic drug in the treatment of various clinical forms of epilepsy.

Author Information

Ferrara, SD
Istituto Medicina Legale, Padua, Italy
Tedeschi, L
Istituto Medicina Legale, Padua, Italy
Marigo, M
Istituto Medicina Legale, Padua, Italy
Castagna, F
Istituto Medicina Legale, Padua, Italy
Pages: 9
Price: $25.00
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Stock #: JFS10790J
ISSN: 0022-1198
DOI: 10.1520/JFS10790J