ISSN: 0022-1198
CODEN: JFSCA
Published Online: 1 January 1979
Page Count: 9

Concentrations of Phenobarbital, Flurazepam, and Flurazepam Metabolites in Autopsy Cases
Castagna, F
Director, Toxicology Section; laurea in chemistry, forensic toxicologist, assistant of the Toxicology Section; professor of legal medicine; and laurea in biology, forensic toxicologist, assistant of the Toxicology Section, Istituto Medicina Legale,

Tedeschi, L
Director, Toxicology Section; laurea in chemistry, forensic toxicologist, assistant of the Toxicology Section; professor of legal medicine; and laurea in biology, forensic toxicologist, assistant of the Toxicology Section, Istituto Medicina Legale,

Marigo, M
Director, Toxicology Section; laurea in chemistry, forensic toxicologist, assistant of the Toxicology Section; professor of legal medicine; and laurea in biology, forensic toxicologist, assistant of the Toxicology Section, Istituto Medicina Legale,

Ferrara, SD
Director, Toxicology Section; laurea in chemistry, forensic toxicologist, assistant of the Toxicology Section; professor of legal medicine; and laurea in biology, forensic toxicologist, assistant of the Toxicology Section, Istituto Medicina Legale,

(Received 21 March 1978; accepted 29 June 1978)

Abstract

Flurazepam hydrochloride (7-chloro-1-(diethylaminoethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride) was synthesized in 1965 by Sternbach et al [1]. It is used clinically as a hypnotic in the treatment of anxiety and depression syndromes as well as an anticonvulsant in association with other drugs. Its pharmacology and metabolism have been extensively studied by various workers [2–4]. The toxicological features of phenobarbital (ethylphenylbarbituric acid) are also almost completely known, and this compound has been used for years as the basic drug in the treatment of various clinical forms of epilepsy.

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Paper ID: JFS10790J
DOI: 10.1520/JFS10790J
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