Volume 24, Issue 1 (January 1979)
Determination at the Nanogram Range of Rilatinic Acid in Urine After Ion-Pair Extraction
Methylphenidate (α-phenyl-2-piperidineacetic acid methyl ester), synthetized by Panizzon , is a central nervous system stimulant of the amphetamine series. It differs from many of the phenylisopropylamines in having moderate effects on the peripheral circulatory system. It is used in the management of hyperkinetic and perceptually handicapped children  where it is claimed to improve both behavior and learning ability . It is not only a doping agent for sportsmen but also an increasing factor in the drug abuse problem. In many countries this drug has been submitted to narcotic regulations.