Volume 24, Issue 1 (January 1979)

    The Screening and Quantitation of Diazepam, Flurazepam, Chlordiazepoxide, and Their Metabolites in Blood and Plasma by Electron-Capture Gas Chromatography and High Pressure Liquid Chromatography

    (Received 11 March 1978; accepted 1 May 1978)

    Published Online: January

    CODEN: JFSOAD

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    Abstract

    The number and frequency of requests made to toxicologists to analyze blood or plasma samples for benzodiazepines are increasing dramatically, but until recently specific and sensitive procedures were unavailable to meet the demand. Gas-liquid chromatography with electron-capture detection has become the analytical method of choice for these drugs because it meets the necessary sensitivity requirements. Prior to the development of this method the available analytical procedures depended on acid hydrolysis of the benzodiazepines to their corresponding benzophenones [1] followed by gas-liquid or thin-layer chromatography. Unfortunately, hydrolysis of several of the benzodiazepines results in the formation of the same benzophenone [2,3] so that the individual parent drugs cannot be readily identified.


    Author Information:

    Kopjak, L
    Associate toxicologists, Center for Human Toxicology, University of Utah, Salt Lake City,

    Peat, MA
    Associate toxicologists, Center for Human Toxicology, University of Utah, Salt Lake City,


    Stock #: JFS10788J

    ISSN: 0022-1198

    DOI: 10.1520/JFS10788J

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    Title The Screening and Quantitation of Diazepam, Flurazepam, Chlordiazepoxide, and Their Metabolites in Blood and Plasma by Electron-Capture Gas Chromatography and High Pressure Liquid Chromatography
    Symposium , 0000-00-00
    Committee E30