(Received 25 July 1977; accepted 16 September 1977)
Published Online: April
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The dynamics of digoxin metabolism have been well studied since the introduction of sensitive radioimmunoassay procedures capable of detecting low biologic levels of this compound . The value of monitoring digoxin therapy through serum levels has been widely accepted, and toxic effects are frequently observed when the serum level of adult individuals exceeds 2 ng/ml [2,3]. Beller et al  reported a twofold increase in mortality among hospitalized patients having digitalis toxicity.
Chief of pathology, Hennepin County Medical Center, Minneapolis, Minn.
Pathologist, St. Paul-Ramsey Hospital, St. Paul, Minn.
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