Antemortem Conversion of Codeine to Morphine in Man

    Volume 21, Issue 3 (July 1976)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 July 1976

    Page Count: 7


    Griesemer, EC
    Head toxicologist, supervising toxicologist, and chief medical examiner-coroner, Los Angeles, Calif.

    Nakamura, GR
    Head toxicologist, supervising toxicologist, and chief medical examiner-coroner, Los Angeles, Calif.

    Noguchi, TT
    Head toxicologist, supervising toxicologist, and chief medical examiner-coroner, Los Angeles, Calif.

    (Received 20 October 1975; accepted 25 November 1975)

    Abstract

    In the routine screening of postmortem specimens in this laboratory, whenever codeine is detected, morphine is almost always found concurrently. Adler [1] and Mannering et al [2] demonstrated that, in man, codeine is demethylated to morphine, and that as much as 17.2% of codeine appears as bound and unbound morphine in urine.


    Paper ID: JFS10525J

    DOI: 10.1520/JFS10525J

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    Author
    Title Antemortem Conversion of Codeine to Morphine in Man
    Symposium , 0000-00-00
    Committee E30