Mass Spectrometry as an Aid in the Detection and Identification of Piperidyl Benzilates and Related Glycolates

    Volume 21, Issue 2 (April 1976)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 April 1976

    Page Count: 12


    Petersen, BA
    Candidate for Ph.D. in chemistry, senior scientist, forensic science coordinator, and Director, Institute of Chemical Analysis, Applications, Boston, Mass.

    Karger, BL
    Candidate for Ph.D. in chemistry, senior scientist, forensic science coordinator, and Director, Institute of Chemical Analysis, Applications, Boston, Mass.

    Parker, JM
    Candidate for Ph.D. in chemistry, senior scientist, forensic science coordinator, and Director, Institute of Chemical Analysis, Applications, Boston, Mass.

    Vouros, P
    Candidate for Ph.D. in chemistry, senior scientist, forensic science coordinator, and Director, Institute of Chemical Analysis, Applications, Boston, Mass.

    (Received 1 August 1975; accepted 18 August 1975)

    Abstract

    In 1958, Abood and co-workers [1] synthesized a series of compounds with the general structure indicated by Compound I (Fig. 1), using the piperidine ring of atropine and replacing the tropic acid side chain with substituted glycolic acids. In recent years, considerable attention has been given to this series of compounds because of their potent anticholinergic and central nervous system (CNS) activity [2–6]. In man, they exhibit powerful, psychotomimetic, and antidepressant symptoms, and, in doses of 1 to 25 mg, produce long-lasting hallucinogenic effects similar in action to lysergic acid diethylamide (LSD). These compounds are also quite toxic and in larger doses can lead to death through respiratory failure.


    Paper ID: JFS10496J

    DOI: 10.1520/JFS10496J

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    Title Mass Spectrometry as an Aid in the Detection and Identification of Piperidyl Benzilates and Related Glycolates
    Symposium , 0000-00-00
    Committee E30