Journal Published Online: 01 April 1976
Volume 21, Issue 2

Mass Spectrometry as an Aid in the Detection and Identification of Piperidyl Benzilates and Related Glycolates

CODEN: JFSCAS

Abstract

In 1958, Abood and co-workers [1] synthesized a series of compounds with the general structure indicated by Compound I (Fig. 1), using the piperidine ring of atropine and replacing the tropic acid side chain with substituted glycolic acids. In recent years, considerable attention has been given to this series of compounds because of their potent anticholinergic and central nervous system (CNS) activity [2–6]. In man, they exhibit powerful, psychotomimetic, and antidepressant symptoms, and, in doses of 1 to 25 mg, produce long-lasting hallucinogenic effects similar in action to lysergic acid diethylamide (LSD). These compounds are also quite toxic and in larger doses can lead to death through respiratory failure.

Author Information

Petersen, BA
Forensic Science, Northeastern University, Boston, Mass.
Vouros, P
Forensic Science, Northeastern University, Boston, Mass.
Parker, JM
Forensic Science, Northeastern University, Boston, Mass.
Karger, BL
Forensic Science, Northeastern University, Boston, Mass.
Pages: 12
Price: $25.00
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Stock #: JFS10496J
ISSN: 0022-1198
DOI: 10.1520/JFS10496J