ISSN: 0022-1198
CODEN: JFSCA
Published Online: 1 April 1976
Page Count: 12

Mass Spectrometry as an Aid in the Detection and Identification of Piperidyl Benzilates and Related Glycolates
Petersen, BA
Candidate for Ph.D. in chemistry, senior scientist, forensic science coordinator, and Director, Institute of Chemical Analysis, Applications, Mass.

Karger, BL
Candidate for Ph.D. in chemistry, senior scientist, forensic science coordinator, and Director, Institute of Chemical Analysis, Applications, Mass.

Parker, JM
Candidate for Ph.D. in chemistry, senior scientist, forensic science coordinator, and Director, Institute of Chemical Analysis, Applications, Mass.

Vouros, P
Candidate for Ph.D. in chemistry, senior scientist, forensic science coordinator, and Director, Institute of Chemical Analysis, Applications, Mass.

(Received 1 August 1975; accepted 18 August 1975)

Abstract

In 1958, Abood and co-workers [1] synthesized a series of compounds with the general structure indicated by Compound I (Fig. 1), using the piperidine ring of atropine and replacing the tropic acid side chain with substituted glycolic acids. In recent years, considerable attention has been given to this series of compounds because of their potent anticholinergic and central nervous system (CNS) activity [2–6]. In man, they exhibit powerful, psychotomimetic, and antidepressant symptoms, and, in doses of 1 to 25 mg, produce long-lasting hallucinogenic effects similar in action to lysergic acid diethylamide (LSD). These compounds are also quite toxic and in larger doses can lead to death through respiratory failure.

Keywords:

Paper ID: JFS10496J
DOI: 10.1520/JFS10496J
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