Journal Published Online: 01 October 1975
Volume 20, Issue 4

The Differential Elution of Drugs from XAD-2 Resin

CODEN: JFSCAS

Abstract

In a previously published XAD-2 resin method for the extraction of drugs from biofluids and tissue [1] the elution of the drug(s) from the resin was accomplished with one or more organic solvents. Drugs exhibiting acid, basic, and neutral characteristics were eluted from the column in the same fraction. Preliminary drug screening was usually carried out by thin-layer chromatography (TLC), employing a spray sequence which can achieve detection of almost all the commonly encountered drugs. This procedure of drug detection and identification requires that the analyst be especially competent in utilizing a spray sequence effectively. A preliminary study was conducted to determine whether the drugs eluted differentially from XAD-2 resin. Herein is presented a technique in which drugs are separated physically into acid or neutral, and basic drug fractions.

Author Information

Pranitis, PAF
Connecticut State Department of Health, Hartford, Conn.
Stolman, A
University of Connecticut School of Medicine, Farmington, Conn.
Pages: 5
Price: $25.00
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Stock #: JFS10325J
ISSN: 0022-1198
DOI: 10.1520/JFS10325J