ISSN: 0022-1198
CODEN: JFSCA
Page Count: 26

Phenothiazines: Metabolism and Analytical Detection
Green, DE
Stanford University School of Medicine, Calif.

Forrest, IS
Stanford University School of Medicine, Calif.

(Received 1 March 1972; accepted 5 June 1972)

Abstract

In the early 1950's chlorpromazine (Thorazine), the first phenothiazine drug for clinical use in man, was synthesized in France, was introduced in Europe and Canada without delay, and has been used on a large scale in this country since 1954. Since its introduction chlorpromazine (CP) has been administered to about 100 million people all over the world, and, therefore, metabolic and toxicologic studies have been conducted in many laboratories. There are more than 10,000 papers on record dealing with clinical, pharmacological and biochemical aspects of its use.

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Paper ID: JFS10149J
DOI: 10.1520/JFS10149J
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