Volume 17, Issue 4 (October 1972)
Phenothiazines: Metabolism and Analytical Detection
In the early 1950's chlorpromazine (Thorazine), the first phenothiazine drug for clinical use in man, was synthesized in France, was introduced in Europe and Canada without delay, and has been used on a large scale in this country since 1954. Since its introduction chlorpromazine (CP) has been administered to about 100 million people all over the world, and, therefore, metabolic and toxicologic studies have been conducted in many laboratories. There are more than 10,000 papers on record dealing with clinical, pharmacological and biochemical aspects of its use.