Determination of Propoxyphene in Biological Materials by Ultraviolet Spectrophotometry and Gas Chromatography

    Volume 17, Issue 1 (January 1972)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 10


    Wallace, JE
    USAF School of Aerospace Medicine, Brooks Air Force Base, Texas

    Blum, K
    USAF School of Aerospace Medicine, Brooks Air Force Base, Texas

    Ladd, SL
    USAF School of Aerospace Medicine, Brooks Air Force Base, Texas

    (Received 7 June 1971; accepted 1 September 1971)

    Abstract

    Propoxyphene has received widespread utilization as an analgesic agent. Originally thought to be nontoxic, the compound in recent years has been reported as a contributing agent in numerous intoxications of which several have been lethal [1]. The compound is a tertiary amino ester, α-d-4-dimethylamino-l-2-diphenyl-3-methyl-2-butanol propionate. Of the four possible stereoisomers only the α-d form has an analgesic effect [2–4]. Since propoxyphene absorbs ultraviolet radiation in the manner characteristic of benzenoid compounds, methods which utilize ultraviolet spectra of unconverted propoxyphene have little application to the analysis of this compound in biological systems [5].


    Paper ID: JFS10125J

    DOI: 10.1520/JFS10125J

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    Title Determination of Propoxyphene in Biological Materials by Ultraviolet Spectrophotometry and Gas Chromatography
    Symposium , 0000-00-00
    Committee E30