ASTM WK46996

    Withdrawal of E1280 - 97(2008) Standard Guide for Performing the Mouse Lymphoma Assay for Mammalian Cell Mutagenicity

    (What is a Work Item?)

    Developed by Subcommittee: F04.16 | Committee F04 | Contact Staff Manager


    This standard is being balloted for withdrawal with no replacement because it has not been revised since 1997 and was developed by committee E47 for aquatic toxicity testing. When balloted for re-approval, a recommendation was recieved that it be withdrawn because there exist better and more complete standards either on the books or in development. This standard would require extensive revision to be re-approved and would duplicate effort in ISO to do so.


    Assay; Carcinogenicity; Chromosomal/genetic effects; Cloning; Cytotoxicity; Data analysis--environmental; Genetic examination; Mammalian cell mutagenicity; Metabolic activation; Mice; MLA (mouse lymphoma assay); Mutagenicity; Plating (cloning) efficiency; Quality assurance (QA)--environmental; Solubility; Spontaneous (background) mutant frequency; Test animals; THMG cleansing; Testing methods; Total growth; Toxicity/toxicology--animals;
    Citing ASTM Standards
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    Work Item Status

    Date Initiated:

    Technical Contact:
    Kenneth St John


    F04 (14-08)

    Ballot Item Approved as E1280-1997(2008) and Pending Publication