ASTM WK45813

    Revision of E1280 - 97(2008) Standard Guide for Performing the Mouse Lymphoma Assay for Mammalian Cell Mutagenicity

    (What is a Work Item?)

    Active Standard: E1280 - 97(2008)

    Developed by Subcommittee: F04.16 | Committee F04 | Contact Staff Manager


    1. Rationale

    The purpose of this revision is to update the standard based on recommendations from international technical committee meetings, clarify definitions, and update appropriate references.


    Assay; Carcinogenicity; Chromosomal/genetic effects; Cloning; Cytotoxicity; Data analysis--environmental; Genetic examination; Mammalian cell mutagenicity; Metabolic activation; Mice; MLA (mouse lymphoma assay); Mutagenicity; Plating (cloning) efficiency; Quality assurance (QA)--environmental; Solubility; Spontaneous (background) mutant frequency; Test animals; THMG cleansing; Testing methods; Total growth; Toxicity/toxicology--animals;
    Citing ASTM Standards
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    Work Item Status

    Date Initiated:

    Technical Contact:
    Christine Bubendorf

    Draft Under Development