ASTM WK45813

    Revision of E1280 - 97(2008) Standard Guide for Performing the Mouse Lymphoma Assay for Mammalian Cell Mutagenicity

    (What is a Work Item?)

    Active Standard: E1280 - 97(2008)

    Developed by Subcommittee: F04.16 | Committee F04 | Contact Staff Manager


    1. Rationale

    At this time, the Standard E1280 is being balloted for withdrawal, so this work item is on hold. The purpose of this revision is to update the standard based on recommendations from international technical committee meetings, clarify definitions, and update appropriate references.


    Assay; Carcinogenicity; Chromosomal/genetic effects; Cloning; Cytotoxicity; Data analysis--environmental; Genetic examination; Mammalian cell mutagenicity; Metabolic activation; Mice; MLA (mouse lymphoma assay); Mutagenicity; Plating (cloning) efficiency; Quality assurance (QA)--environmental; Solubility; Spontaneous (background) mutant frequency; Test animals; THMG cleansing; Testing methods; Total growth; Toxicity/toxicology--animals;
    Citing ASTM Standards
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    Work Item Status

    Date Initiated:

    Technical Contact:
    Kenneth St John

    Draft Under Development