ASTM WK45813

    Revision of E1280 - 97(2008) Standard Guide for Performing the Mouse Lymphoma Assay for Mammalian Cell Mutagenicity

    (What is a Work Item?)

    Active Standard: E1280 - 97(2008)

    Developed by Subcommittee: F04.16 | Committee F04 | Contact Staff Manager



    WK45813

    1. Rationale

    The purpose of this revision is to update the standard based on recommendations from international technical committee meetings, clarify definitions, and update appropriate references.


    Keywords

    Assay; Carcinogenicity; Chromosomal/genetic effects; Cloning; Cytotoxicity; Data analysis--environmental; Genetic examination; Mammalian cell mutagenicity; Metabolic activation; Mice; MLA (mouse lymphoma assay); Mutagenicity; Plating (cloning) efficiency; Quality assurance (QA)--environmental; Solubility; Spontaneous (background) mutant frequency; Test animals; THMG cleansing; Testing methods; Total growth; Toxicity/toxicology--animals;
    Citing ASTM Standards
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    Work Item Status

    Date Initiated:
    04-24-2014

    Technical Contact:
    Christine Bubendorf

    Status:
    Draft Under Development