To describe general principles of developing and/or using an in vitro assay to evaluate biomolecule release from biomaterials scaffolds for TEMPs. The guide will address scaffolds that do not contain seeded cells; general principles may still apply but may need to be modified if cells are part of the TEMPs. The guide addresses TEMPs where it matters that some of the biomolecule remains available on the matrix, or needs to be released into the surrounding tissue for efficacy (e.g. cytokines).
in vitro release of biomolecules from matrices is a valuable tool for screening as well as characterization, and/or quality control.
biomolecule/biomaterial combination, release medium, assay selection
The title and scope are in draft form and are under development within this ASTM Committee.
Citing ASTM Standards
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